In this review, martens et al. Propose a novel “apoe cascade hypothesis” that the biochemical and biophysical properties of apoe impact a cascade of events at the cellular and systems. Altmann a, aksman lm, oxtoby np, young a, alzheimer'sdiseaseneuroimaginginitative(adni), alexander dc, barkhof f, shoai m, hardy j, schott jm. Towards cascading genetic risk in. May 31, 2024 · using longitudinal data from the alzheimer’s disease neuroimaging imitative (adni) and survival analysis, we show that apoe contributes to progression from a−t− to a+t−, but only marginally from a+t− to a+t+.
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